The main activity of the N.A.T.U.R.&. Onlus Association is 'Casa Aperta' (or 'Open Home'), a home for troubled youth for whom their families and communities do not offer adequate support. Casa Aperta was created thanks to the adaptation of a section of Villa Dho in Seveso (a town in Northern Italy).

The project is flanked by a network of services that offer support to parents who find themselves in difficulty in caring for their children. The initiative provides foster care, day care, family reunification, temporary housing for minors until they reach 21 years of age.